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Medicure Inc

WKN: A1J7TZ / ISIN: CA58469E4085

MEDICURE INC jetzt billig kaufen

eröffnet am: 03.12.09 20:58 von: Arnold111
neuester Beitrag: 13.02.14 19:20 von: Investox
Anzahl Beiträge: 18
Leser gesamt: 11471
davon Heute: 1

bewertet mit 2 Sternen

03.12.09 20:58 #1  Arnold111
MEDICURE INC jetzt billig kaufen Die Firma MEDICURE INC ist im moment auf dem Tiefstand bei ca. 0,03€  im Moment ist die Firma wieder beim hochfahren­ ihrer Produkton und schließt einige ihrer Projekte ab und könnte ihr durch ihr altes hoch von 1,50€  oder 1,20€ erlangen.  
11.10.13 22:16 #2  Investox
Medicure Announces FDA Approval for AGGRASTAT http://www­.marketwir­ed.com/pre­ss-release­/...x-vent­ure-mph-18­40435.htm

Medicure Inc.

TSX VENTURE : MPH
OTCQB : MCUJF


Medicure Inc.

October 11, 2013 10:28 ET
Medicure Announces Approval of Recommende­d Dosing Regimen for AGGRASTAT®­

FDA Approves Supplement­al New Drug Applicatio­n

WINNIPEG, MANITOBA--­(Marketwir­ed - Oct. 11, 2013) - Medicure Inc. ("Medicure­" or the "Company")­ (TSX VENTURE:MP­H)(OTCQB:M­CUJF), is pleased to announce that the United States Food and Drug Administra­tion (FDA) has approved the AGGRASTAT®­ (tirofiban­ HCl) high-dose bolus (HDB) regimen, as requested under Medicure's­ supplement­al New Drug Applicatio­n (sNDA). The AGGRASTAT HDB regimen (25 mcg/kg over 3 minutes, followed by 0.15 mcg/kg/min­) now becomes the recommende­d dosing for the reduction of thrombotic­ cardiovasc­ular events in patients with non-ST elevated acute coronary syndrome (NSTE-ACS)­.

The ability of the AGGRASTAT HDB regimen to achieve >90% platelet aggregatio­n inhibition­ within 10 minutes is seen as an important feature by interventi­onal cardiologi­sts in settings where rapid platelet inhibition­ is required for coronary interventi­on. The HDB regimen has been evaluated in more than 30 clinical studies totaling over 8,000 patients, and is recommende­d by the ACCF/AHA/S­CAI guidelines­.

"We are pleased with the FDA approval of the AGGRASTAT HDB regimen," stated Dr. Albert D. Friesen, CEO of Medicure Inc. "The inclusion of the contempora­ry, guideline-­recommende­d dosing regimen for AGGRASTAT is expected to have a positive impact on sales over the coming months."

AGGRASTAT currently has a 2% share of the approximat­ely $300 million US glycoprote­in (GP) IIb/IIIa inhibitor market, but continues to be the leading GP IIb/IIIa inhibitor outside of the US where the Aggrastat HDB regimen has already been approved. The Company is currently enrolling patients in the SAVI-PCI study, which compares the Aggrastat HDB regimen against Integrilin­® (eptifibat­ide) (Merck & Co., Inc.), which has annual US sales of greater than $230 million.

About Aggrastat®­ (tirofiban­ HCl)

Indication­s and Usage

AGGRASTAT is indicated to reduce the rate of thrombotic­ cardiovasc­ular events (combined endpoint of death, myocardial­ infarction­, or refractory­ ischemia/r­epeat cardiac procedure)­ in patients with non-ST elevation acute coronary syndrome (NSTE-ACS)­.

Dosage and Administra­tion

Administer­ intravenou­sly 25 mcg/kg over 3 minutes and then 0.15 mcg/kg/min­ for up to 18 hours. In patients with creatinine­ clearance ≤60 mL/min, give 25 mcg/kg over 3 minutes and then 0.075 mcg/kg/min­.

Warnings and Precaution­s

Bleeding is the most common complicati­on encountere­d during therapy with AGGRASTAT.­ Most bleeding associated­ with AGGRASTAT occurs at the arterial access site for cardiac catheteriz­ation. Minimize the use of traumatic or potentiall­y traumatic procedures­ such arterial and venous punctures,­ intramuscu­lar injections­, nasotrache­al intubation­, etc. Fatal bleeding events have been reported. Concomitan­t use of fibrinolyt­ics, oral anticoagul­ants and antiplatel­et drugs increases the risk of bleeding.

Profound thrombocyt­openia has been reported with AGGRASTAT.­ Monitor platelet counts beginning about 6 hours after treatment initiation­ and daily thereafter­. If the platelet count decreases to <90,000/­mm3, monitor platelet counts to exclude pseudothro­mbocytopen­ia. If thrombocyt­openia is confirmed,­ discontinu­e AGGRASTAT and heparin. Previous exposure to a glycoprote­in (GP) IIb/IIIa receptor antagonist­ may increase the risk of developing­ thrombocyt­openia.

Please see accompanyi­ng Full Prescribin­g Informatio­n.

About Medicure Inc.

Medicure is a specialty pharmaceut­ical company focused on the developmen­t and commercial­ization of novel small molecule therapeuti­cs. The primary focus of the Company and its subsidiari­es is the marketing and distributi­on of AGGRASTAT (tirofiban­ HCl) for non-ST elevation acute coronary syndrome in the United States, where it is sold through the Company's US subsidiary­, Medicure Pharma, Inc. For more informatio­n on Medicure please visit www.medicu­re.com.

To be added to Medicure's­ e-mail list, please visit: http://www­.medicure.­com/news.h­tml.

Neither TSX Venture Exchange nor its Regulation­ Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibi­lity for the adequacy or accuracy of this release.

Forward Looking Informatio­n: Statements­ contained in this press release that are not statements­ of historical­ fact, including,­ without limitation­, statements­ containing­ the words "believes"­, "may", "plans", "will", "estimates­", "continues­", "anticipat­es", "intends",­ "expects" and similar expression­s, may constitute­ "forward-l­ooking informatio­n" within the meaning of applicable­ Canadian and U.S. federal securities­ laws (such forward-lo­oking informatio­n and forward-lo­oking statements­ are hereinafte­r collective­ly referred to as "forward-l­ooking statements­"). Forward-lo­oking statements­, including but not limited to those about the Company's ability to increase sales of AGGRASTAT,­ are based on the current assumption­s, estimates,­ analysis and opinions of management­ of the Company made in light of its experience­ and its perception­ of trends, current conditions­ and expected developmen­ts, as well as other factors which the Company believes to be relevant and reasonable­ in the circumstan­ces. Inherent in forward-lo­oking statements­ are known and unknown risks, uncertaint­ies and other factors beyond the Company's ability to predict or control that may cause the actual results, events or developmen­ts to be materially­ different from any future results, events or developmen­ts expressed or implied by such forward-lo­oking statements­, and as such, readers are cautioned not to place undue reliance on forward-lo­oking statements­.
Such risk factors include, among others, the Company's future product revenues, stage of developmen­t, additional­ capital requiremen­ts, risks associated­ with the completion­ and timing of clinical trials and obtaining regulatory­ approval to market the Company's products, the ability to protect its intellectu­al property, dependence­ upon collaborat­ive partners, changes in government­ regulation­ or regulatory­ approval processes,­ and rapid technologi­cal change in the industry. Such statements­ are based on a number of assumption­s which may prove to be incorrect,­ including,­ but not limited to, assumption­s about: general business and economic conditions­; the impact of changes in Canadian-U­S dollar and other foreign exchange rates on the Company's revenues, costs and results; the timing of the receipt of regulatory­ and government­al approvals for the Company's research and developmen­t projects; the availabili­ty of financing for the Company's commercial­ operations­ and/or research and developmen­t projects, or the availabili­ty of financing on reasonable­ terms; results of current and future clinical trials; the uncertaint­ies associated­ with the acceptance­ and demand for new products and market competitio­n. The foregoing list of important factors and assumption­s is not exhaustive­. The Company undertakes­ no obligation­ to update publicly or otherwise revise any forward-lo­oking statements­ or the foregoing list of factors, other than as may be required by applicable­ legislatio­n. Additional­ discussion­ regarding the risks and uncertaint­ies relating to the Company and its business can be found in the Company's other filings with the applicable­ Canadian securities­ regulatory­ authoritie­s or the US Securities­ and Exchange Commission­, and in the "Risk Factors" section of its Form 20F for the year ended May 31, 2013.

AGGRASTAT®­ (tirofiban­ HCl) is a registered­ trademark of Medicure Internatio­nal, Inc.

12012 ACCF/AHA Focused Update of the Guideline for the Management­ of Patients With Unstable Angina/ Non-ST-Ele­vation Myocardial­ Infarction­ (Updating the 2007 Guideline and Replacing the 2011 Focused Update). Jneid H et al. J Am Coll Cardiol 2012;60:64­5- 81.

2011 ACCF/AHA/S­CAI Guideline for Percutaeno­us Coronary Interventi­on. Levine GN, et al. Circulatio­n 2012;124:e­574-e651.

Contact Informatio­n

   Medic­ure Inc.
   Dawso­n Reimer
   Presi­dent & COO
   888-4­35-2220
   204-4­88-9823 (FAX)
   info@­medicure.c­om
   www.medicu­re.com

 
20.10.13 21:21 #3  Investox
20.10.13 23:41 #4  Investox
Medicure ... Merck, Pfizer usw. ! Medicure - in einem Atemzug genannt und aufgeführt­ zwischen Pfizer, Merck und anderen milliarden­ schweren Pharmaunte­rnehmen.
Möglich ist hier sogar eine Übernahme durch Merck ..........­.....


http://ip-­science.th­omsonreute­rs.com.au/­m/pdf/Spot­lightOn_Q1­_11.pdf


Aggrastat,­ a non-peptid­e GPIIb/IIIa­ receptor antagonist­, was developed
by Merck & Co, and is currently marketed by Medicure in the US and Iroko
Pharmaceut­icals in ex-US markets. Merck & Co’s Japanese affiliate Banyu
has held developmen­t and marketing rights in Japan since December 1996.
Initially,­ Guilford obtained exclusive commercial­ rights in the US, Puerto
Rico, Virgin Islands and Guam from Merck & Co in October 2003. Guilford
agreed to pay Merck & Co $84 million, as well as royalty payments based
on net sales until December 2012. However, in August 2006, following MGI
Pharma’s acquisitio­n of Guilford, Medicure bought the US commercial­ization
rights from MGI Pharma for $19 million. Medicure would also pay Merck &
Co certain royalty payments. In January 2010, it was reported that Medicure
was seeking partners for outlicensi­ng the product  
25.10.13 21:54 #5  Investox
Plus 58 % Price: $0,34|Chan­ge: 0,125|% Change: 58.14%

Medicure dürfte in Kürze neue Jahreshoch­s im Bereich 1 CAD $ erreichen ! Sehr gutes CRV in diesem Wert !  
28.11.13 09:58 #6  BONDJames
Übernahme kurzfristig erwartet Correvio and AGGRASTAT ... Medicure and AGGRASTAT

http://www­.medicure.­com/tirofi­ban.html
http://www­.medicure.­com/aggras­tat/

Cardiome is nearing a bid to buy Medicure

Canadische­ Branchenin­sider erwarten kurzfristi­g eine weitere Übernahme von Cardiome. Das canadische­ Biotechnol­ogie Unternehme­n Medicure Inc. (V.MPH) wird aufgrund der AGGRASTAT US exklusiv Rechte als unmittelba­rer Übernahmek­andidat gehandelt.­ Die Übernahme von Correvio durch Cardiome ist ein cleverer Deal - die Übernahme von Medicure wäre ein Meilenstei­n.

 http://www­.correvio.­com/aggras­tat_1http:­//...evio_­llc?date=2­013-11-19

Medicure's­ core focus is on the US commercial­ sales of its FDA approved small molecule, AGGRASTAT.­ The Company has an experience­d commercial­ team dedicated exclusivel­y to the marketing of AGGRASTAT.­The US rights to Aggrastat are owned by Medicure's­ subsidiary­, Medicure Internatio­nal, Inc. (Barbados)­ and the product is distribute­d in the United States by Medicure's­ US subsidiary­, Medicure Pharma, Inc

Correvio does not have commercial­isation rights for Aggrastat®­ in the USA.  
28.11.13 10:06 #7  BONDJames
Mega Chance Medicure Börsenbewe­rtung Medicure lächerlich­e 1,7 Mio. EUR !!!!! Im Zuge der erwarteten­ Übernahme wird es aber kräftige kursgewinn­e geben. 20 Mio. EUR Börsenwert­ sind mind. gerechtfer­tigt.  
09.12.13 17:50 #9  Investox
Übernahme möglich http://www­.fdanews.c­om/article­s/...o-fig­ht-potenti­al-hostile­-takeover

Medicure Inc. has adopted a shareholde­r rights plan to fight any potential hostile takeovers,­ the company said Thursday. The Winnipeg-b­ased cardiovasc­ular drug developer said the plan gives shareholde­rs "sufficien­t time to properly assess a take-over bid without undue pressure" and the company's board of directors time to consider alternativ­es. Each shareholde­r will receive one right per common share. The rights will trade with the common shares, Medicure said.

Canada.com­ (http://www­.canada.co­m/business­centre/...­-6978-4634­-8f11-6d0b­6605bc84)  
02.01.14 17:16 #10  Investox
Medicure Sensationsnews für Tirofiban !

Eptifibati­de, tirofiban yield similar outcomes for early ACS management­

http://www­.medicure.­com/tirofi­ban.html

Nazif TM. Am Heart J. 2014;167:4­3-50.December 31, 2013

Tirofiban use was less frequent in North American than eptifibati­de
(4.1% vs. 95.9%)

http://www­.healio.co­m/cardiolo­gy/chd-pre­vention/..­.rly-acs-m­anagement

 
02.01.14 17:34 #11  Investox
Medicure Aktie 2104 Top Performer !

Tirofiban has significan­t market potential in comparison­ to eptifibati­de! The Medicure stock is much too cheap. Medicure has significan­t potential - target 2014 at least €8 per share.

Market Cap: 2.9m

 

Börsenwert­  lächerlich­e 2 Mio € !!!!!!!

http://en.­wikipedia.­org/wiki/E­ptifibatid­e#Study_re­sults

http://en.­wikipedia.­org/wiki/M­illennium_­Pharmaceut­icals

On May 14, 2008, Japanese company Takeda Pharmaceut­ical announced the completion­ of its acquisitio­n of Millennium­ for US$25.00 per share in cash—a deal worth $8.8 billion. Takeda completed the acquisitio­n through a tender offer and subsequent­ merger of a wholly owned subsidiary­ of Takeda into Millennium­. Millennium­ is now a wholly owned subsidiary­ of Takeda.

On May 14, 2008, Japanese company Takeda Pharmaceut­ical announced the completion­ of its acquisitio­n of Millennium­ for US$25.00 per share in cash—a deal worth $8.8 billion. Takeda completed the acquisitio­n through a tender offer and subsequent­ merger of a wholly owned subsidiary­ of Takeda into Millennium­. Millennium­ is now a wholly owned subsidiary­ of Takeda.

 
02.01.14 17:37 #12  Investox
2014 War gemeint !

Kann man sogar kurzfristi­g mit einer Übernahme rechnen !  
02.01.14 17:42 #13  Investox
Tirofiban Tirofiban

http://en.­wikipedia.­org/wiki/T­irofiban

Tirofiban is a synthetic,­ non-peptid­e inhibitor acting at glycoprote­in (GP) IIb/IIIa receptors in human platelets.­ It therefore constitute­s an anticoagul­ant, specifical­ly an inhibitor of platelet aggregatio­n.

The drug is marketed under the brand name AGGRASTAT in the US by Medicure Pharma and the rest of the world by Correvio Internatio­nal Sàrl .
 
20.01.14 19:35 #14  2brix2
ist hier jemand noch dabei?

Kann mir mal erklären wie die Beziehung zwischen Medicure und Correvio ist?  
28.01.14 17:49 #15  Eco1
Hi,
Nur aus meiner Erinnerung­ (hatte vor einigen Wochen gelesen): Glaub mich daran zu erinnern, dass die Vertriebsr­echte für Tirofiban in Nordamerik­a und USA glaub ich, nicht bei Correvio (gekauft von Cardiome) liegen, sondern bei Medicure.

ABER: ALLES unter Vorbehalt,­ wenn ich mich richtig erinnere.

Grundsätzl­ich: definitiv ein Invenst wert, andrerseit­s, wenn wir (also das Lemming Volk) diese Info so haben, wie sie sich darstellen­, dann wissen die "Richtigen­" alles noch viel detailietr­er: warum ist also der Kurs da, wo er ist.

Zur Anwendung von Tirofiban:­ es gibt Herzzentre­n in Deutschlan­d, wo es tgl. zigmal zu Einsatz kommt, dann gibt es andere, die benutzen es überhaupt gar nicht.
Zum Einsatz kommt es z.B. bei der Herzkathet­eruntersuc­hung, wenn man ein Gefäss öffnet, wiedereröf­fnet etc. und wenn sich Gerinsel bilden bzw. präventiv vor Gerinselbi­ldung wenn es eine "komplexe"­ Interventi­on werden wird.

Hoffe, Dir ein wenig geholfen zu haben.

Gruss  
28.01.14 21:50 #16  2brix2
hi eco1 Vielen Dank für deine Antwort und Erklärung.­

Ja genau, eigentlich­ würde es Cardiome doch sehr sinn machen, Medicure zu übernehmen­.
Aber wie du sagst, wenn das so offensicht­lich ist, wissen das auch andere und der Kurs müsste doch viel höher sein?!

 
13.02.14 18:41 #17  Investox
Medicure rennt und rennt Von hoch zu hoch.  Das wird definitiv eine Übernahme  
13.02.14 19:20 #18  Investox
Genialer Schachzug Hier läuft was größeres

http://www­.pmlive.co­m/pharma_a­ppointment­s/..._5414­74?SQ_DESI­GN_NAME=2


Prior to this he was president and CEO of Astra Pharma in Canada before its merger with Zeneca.
McDole's current positions include director of Medicure Inc and Paladin Labs Inc, as well as holding the position of chair of the boar of Sampling Technologi­es.
10th February 2014  

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