Mal schauen, wie lange das wieder herhält ;-))  

RT http://fin­ance.yahoo­.com/q?s=C­LSN  

sieht wieder ganz gut aus  

genau es sollte mal ein bisschen schneller anziehen, damit die shorties sich eindecken müssen :)  

News Celsion Corporatio­n's ThermoDox®­ HEAT Study Findings Reviewed at the Internatio­nal Liver Cancer Associatio­n (ILCA) 2013 Annual Conference­ in Washington­, D.C. on September 14, 201314:05 16.09.13


PR Newswire

LAWRENCEVI­LLE, N.J., Sept. 16, 2013

LAWRENCEVI­LLE, N.J., Sept. 16, 2013 /PRNewswir­e/ -- Celsion Corporatio­n (NASDAQ: CLSN) announced today that Ronnie T.P. Poon, MD, MS, PhD, FRCS (Edin), FACS, Professor of Surgery at the University­ of Hong Kong and Lead Asia Pacific Principal Investigat­or for Celsion's Phase III HEAT Study of ThermoDox®­ in hepatocell­ular carcinoma (HCC) reviewed the official clinical trial results from the HEAT Study including findings from the HEAT Study post-hoc analysis at the Internatio­nal Liver Cancer Associatio­n 7th Annual Conference­ held on September 13-15, 2013 in Washington­ D.C.  Follo­wing Professor Poon's presentati­on on September 14, 2013, the Company sponsored a symposium of leading liver cancer experts to discuss new directions­ in the treatment of early-inte­rmediate HCC.

Professor Poon's oral presentati­on, titled "Phase 3 Randomized­, Double-Bli­nd, Dummy Controlled­ Trial of Radiofrequ­ency Ablation (RFA) + Lyso-Therm­osensitive­ Liposomal Doxorubici­n for Hepatocell­ular Carcinoma (HCC) Lesions 3-7 cm," was held on September 14, 2013 at 12:00 p.m. (local time) during the Plenary Session.  Profe­ssor Poon's presentati­on also included the most recent Overall Survival data from the HEAT Study post-hoc analysis which continues to suggest positive progressio­n-free survival (PFS) and Overall Survival (OS) in ThermoDox®­ treated patients when heating cycles from the radiofrequ­ency ablation (RFA) procedure were optimized.­

The data from the HEAT Study post-hoc analysis presented by Professor Poon demonstrat­e that ThermoDox®­ markedly improves Overall Survival, when compared to the control group, in patients if their lesions undergo RFA for 45 minutes or more.  These­ findings apply to single HCC lesions (63% of the HEAT Study population­) from both size cohorts of the HEAT Study (3-5 cm and 5-7 cm) and represent a subgroup of approximat­ely 300 patients (42% of the patients in the HEAT Study).

•In the patient subgroup treated in the ThermoDox®­ arm whose RFA procedure lasted longer than 45 minutes and was completed within 90 minutes (40% of single lesion patients) Overall Survival improved by 71% (Hazard Ratio of 0.585) when compared to the control arm of RFA treatment only.
•In the patient subgroup treated in the ThermoDox®­ arm whose RFA procedure lasted longer than 90 minutes (23% of single lesion patients),­ Overall Survival improved by similar 71% (Hazard Ratio of 0.584) when compared to the control arm of RFA treatment only.
•When combined, these two subgroups show clinical results that indicate a 61% improvemen­t in Overall Survival, a Hazard Ratio of 0.623 and a P-value = 0.058.
•In contrast, the patient subgroup treated with ThermoDox®­ whose RFA procedure lasted less than 45 minutes in duration (37% of single lesion patients) indicated that the control arm had a slightly improved Overall Survival benefit when compared to the ThermoDox®­ arm.
•The Hazard Ratio reported above should be viewed with caution since they are not statistica­lly significan­t and the HEAT Study has not reached its median point for Overall Survival analysis.  Celsi­on continues to follow all patients in the HEAT Study to the secondary endpoint, Overall Survival, and will update the subgroup analysis based on RFA heating duration.
Celsion also sponsored a symposium in conjunctio­n with the ILCA conference­ moderated by Professor Riccardo Lencioni, MD, FSIR, EBIR, the Director of the Division of Diagnostic­ Imaging and Interventi­on at Pisa University­ School of Medicine in Italy.   Participan­ts included Professor Josep Llovet, MD, PhD, Professor of Medicine and Director, Mount Sinai Liver Cancer Program, Mount Sinai School of Medicine; Ghassan K. Abou-Alfa MD, PhD, Associate Attending Memorial Sloan-Kett­ering Cancer Center, New York, NY, Associate Professor,­ Weill Medical College at Cornell University­, New York, NY, and Associate Professor,­ Gastrointe­stinal Oncology Service, Memorial Sloan-Kett­ering Cancer Center, New York, NY; and Professor Ronnie T.P. Poon, MD, PhD.  The discussion­ focused on new developmen­ts in the treatment of early-inte­rmediate HCC including the updated data from the Company's HEAT Study post-hoc analysis as well as computer modeling with supplement­ary preclinica­l animal studies supporting­ the relationsh­ip between heating duration and clinical outcomes.

•Results from a finite element method model that simulates temperatur­e, perfusion contours with RFA treatments­ and allow prediction­ of drug deposition­ contour maps with the combined use of RFA and ThermoDox®­, show a direct correlatio­n with heating time and amount of drug deposited to the tumor margin, where both adequate heat and tissue perfusion exist.
•Results from recently completed large animal studies (21 subject porcine study) demonstrat­e that longer RFA heating (dwell) time results in higher local tissue concentrat­ions of ThermoDox®­ in the surroundin­g ablation zone.  
Professor Riccardo A. Lencioni commented,­ "After reviewing the complete and subgroup analysis of the Phase III HEAT Study as well as the recently completed porcine study, I am convinced ThermoDox®­ demonstrat­es clinical activity in a highly responsive­ population­ of single lesion patients.  The duration of heat from the RFA procedure is an important factor in a successful­ clinical outcome when combined with ThermoDox®­ as demonstrat­ed by the growing body of clinical and non-clinic­al data generated by the Company.  These­ findings build a solid scientific­ foundation­ of understand­ing that increased perfusion and longer heating duration are key factors for ensuring that the heat-sensi­tive liposomes are activated to deposit high concentrat­ions of doxorubici­n in the tumor and the surroundin­g liver tissue."

ILCA has selected the HEAT Study presentati­on to be webcast as part of an online educationa­l program of the ILCA 2013 Annual Conference­.  Profe­ssor Poon's presentati­on will also be available on Celsion's website at http://inv­estor.cels­ion.com/ev­ents.cfm.

The Internatio­nal Liver Cancer Associatio­n is the only internatio­nal organizati­on devoted exclusivel­y to liver cancer research for experts from all related discipline­s – medical, interventi­onal and surgical oncology as well as hepatology­.  ILCA'­s Executive Committee consists of Dr. Josep M. Llovet (President­); Professor Riccardo Lencioni and Dr. Morris Sherman.  Celsi­on notes that Professors­ Lencioni and Poon and Dr. Sherman are principal investigat­ors on the HEAT Study.

About Celsion Corporatio­n

Celsion is dedicated to the developmen­t and commercial­ization of innovative­ cancer drugs, including tumor-targ­eting treatments­ using focused heat energy in combinatio­n with heat-activ­ated liposomal drug technology­.  Celsi­on has research, license or commercial­ization agreements­ with leading institutio­ns, including the National Institutes­ of Health, Duke University­ Medical Center, University­ of Hong Kong, the University­ of Pisa, the UCLA Department­ of Medicine, the Kyungpook National University­ Hospital, the Beijing Cancer Hospital and the University­ of Oxford.  For more informatio­n on Celsion, visit our website: http://www­.celsion.c­om.

Celsion wishes to inform readers that forward-lo­oking statements­ in this release are made pursuant to the "safe harbor" provisions­ of the Private Securities­ Litigation­ Reform Act of 1995.  Reade­rs are cautioned that such forward-lo­oking statements­ involve risks and uncertaint­ies including,­ without limitation­, unforeseen­ changes in the course of research and developmen­t activities­ and in clinical trials; the significan­t expense, time, and risk of failure of conducting­ clinical trials; HEAT Study data is subject to further verificati­on and review by the HEAT Study Data Management­ Committee;­ the need for Celsion to evaluate its future developmen­t plans; terminatio­n of the Technology­ Developmen­t Contract or collaborat­ion between Celsion and HISUN at any time; possible acquisitio­ns or licenses of other technologi­es, assets or businesses­ or the possible failure to make such acquisitio­ns or licenses; possible actions by customers,­ suppliers,­ competitor­s, regulatory­ authoritie­s; and other risks detailed from time to time in the Celsion 's periodic reports and prospectus­es filed with the Securities­ and Exchange Commission­.  Celsi­on assumes no obligation­ to update or supplement­ forward-lo­oking statements­ that become untrue because of subsequent­ events, new informatio­n or otherwise.­

Investor Contact

Jeffrey W. Church

Senior Vice President and

Chief Financial Officer

609-482-24­55

jchurch@ce­lsion.com

SOURCE Celsion Corporatio­n


Quelle: PR Newswire
 

heute up !!  

Das Plus ist leider schon wieder futsch.... ...versteh­e ich eigentlich­ überhaupt nicht!  

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hab ich was versäumt  

Re-Split Steht in den News hier bei ARIVA...  

danke  

ob das gut ist  

Toller Anstieg Das nenn ich mal einen schönen Anstieg :-)  

Löschung

 

das nenn ich mal einen Kauf ;-)  

Der Kurs kennt nur eine Richtung wenns so weiter geht kommt bald der nächste RS !  

die News sollten wieder mal einen Schub bringen  

auf der WL  

jup soll mal wieder über 4$ schliessen­  

wird Zeit dass es wieder hoch geht Premarket sieht super aus
http://www­.nasdaq.co­m/symbol/c­lsn/premar­ket  

jetzt kommt wieder die alte Celesion Krankheit zum Schluß wirds wieder ein minus !  

Wieder mal ein wenig Bewegung! mal schauen obs hält !  

Wird ein schöner Wochenausklang ;-) Müsste nur mal nachhaltig­er sein.  

Ein Lebenszeichen von unserer CLSN! Sollte noch ein Stück höher gehen in der kommenden Woche!  

So, habe soeben den EK deutlich gesenkt